Furthermore, most of inhaled steroids' superiority is in improving objective measures such as lung function which patients may or may not notice ; when considering patient-centered outcomes like daily symptoms and quality of life, montelukast came out about equal to inhaled glucocorticoid as a first-line asthma controller medication, from clinical trials. Experts postulate that this could be due to easier adherence with taking a daily pill, compared to patients' notoriously low adherence rate with inhaled steroids.
All this is why Marc Peters-Golden gave montelukast a cautious endorsement as an alternative first-line asthma therapy in his UpToDate topic review on the drug:. But most physicians are probably not prescribing montelukast as first-line replacement for inhaled steroids, but rather in addition to them as so-called "step-up" therapy. There is good evidence for Singulair's efficacy when used in this manner, but in most studies it was not quite as effective as a long-acting beta agonist LABA added to inhaled steroids.
In a few studies, montelukast was equi-efficacious to LABAs as add-on therapy, and there seem to be many patients in whom Singulair works very well, likely due to heterogeneity not only in response to montelukast, but in response to the inhaled therapies too. Other specific situations in which there is evidence for montelukast's efficacy over other agents include aspirin-sensitive asthma, exercise-induced asthma, and viral upper respiratory infection-induced bronchospasm in children.
Behavior and mood-related changes have been reported: agitation including aggressive behavior or hostility, bad or vivid dreams, depression, disorientation confusion , feeling anxious, hallucinations seeing or hearing things that are not really there , irritability, restlessness, sleepwalking, suicidal thoughts and actions including suicide , tremor, and trouble sleeping. Learn More. Teva Product Catalog The product catalog provides you with a full listing of Teva's brand and generic product lines.
Where can I find Teva medications? Are generic drugs as safe as brand-name drugs? Get Informed Sign up to receive email communication from Teva when new cost-saving Teva generics become available and other health information. We decided a stronger warning is needed after conducting an extensive review of available information and convening a panel of outside experts, and therefore determined that a Boxed Warning was appropriate.
It is a prescription medicine approved to prevent asthma attacks and for the long-term treatment of asthma in adults and children 1 year and older. It is approved to prevent exercise-induced asthma in patients 6 years and older.
Montelukast is also approved to control the symptoms of allergic rhinitis, also known as hay fever, such as sneezing, stuffy nose, runny nose, and itching of the nose. It is used to treat seasonal outdoor allergies in patients 2 years and older, and year-round indoor allergies in patients 6 months and older.
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